SORL1 knockout, knockin, and transgenic mice are now in the Research Models database. The database will be updated as more models become available.

Multiple due dates; see announcement.

Applications will be accepted that request a single, commercially available instrument or an integrated instrumentation system. The minimum award is $750,001. There is no upper limit on the cost of ...

These tau knockout rats were created through transcription activator-like effector nuclease (TALEN)-mediated targeting of exon 2 of the rat Mapt gene (Ayers, Lopez et al., 2024). Tau protein was ...

Tg12099 rats overexpress the 0N4R isoform of human tau with the P301S mutation linked to frontotemporal dementia. The MAPT transgene is driven by the rat Prnp promoter. Overexpress the 0N4R isoform of ...

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These observations open the door to more in-depth investigations looking into a potential mechanistic link between TMEM106b aggregation and pathological processes in neurodegeneration,” Rothstein ...

Lipids Open the Door. Microglial cells treated with unlipidated (top) or lipidated (bottom) ApoE (yellow) along with fluorescently tagged Aβ (green). Lipidated ApoE was more readily internalized and ...

This transgenic mouse model expresses a floxed ATPase type 13A2 (Atp13a2) gene, with loxP sites flanking exons 2 to 3 (The Jackson Laboratory). The ATP13A2 protein is a transmembrane lysosomal ATPase ...