These observations open the door to more in-depth investigations looking into a potential mechanistic link between TMEM106b aggregation and pathological processes in neurodegeneration,” Rothstein ...

Lipids Open the Door. Microglial cells treated with unlipidated (top) or lipidated (bottom) ApoE (yellow) along with fluorescently tagged Aβ (green). Lipidated ApoE was more readily internalized and ...

Far from a static barrier, the brain’s extensive interface with the blood is increasingly being appreciated as an active border, one that serves not only to keep some proteins out, but to let others ...

This transgenic mouse model expresses a floxed ATPase type 13A2 (Atp13a2) gene, with loxP sites flanking exons 2 to 3 (The Jackson Laboratory). The ATP13A2 protein is a transmembrane lysosomal ATPase ...

SORL1 knockout, knockin, and transgenic mice are now in the Research Models database. The database will be updated as more models become available.