Kickoff is set for 8:15 p.m. ET on Saturday at SoFi Stadium. The Rams are favored by 6.5 points in the latest Rams vs. Cardinals odds, while the over/under is 47.5. Before entering any Cardinals vs. Rams picks, you'll want to see the NFL predictions from the model at SportsLine.

It's an NFC West showdown in Week 17 that could drastically change the landscape of the division. The Los Angeles Rams, after a 1-4 start to the season, have won eight of their last ten, but this upcoming matchup against the Arizona Cardinals could put a halt to their hot streak.

The Seahawks beat the Bears on Thursday, so the Rams could clinch the NFC West with a Saturday win over the Cardinals and a "strength of victory" tiebreaker.