Symptoms of Cushing's syndrome include weight gain, a round "moon" face, easy bruising, fat around the base of the neck and the shoulders, stretch marks around the abdomen, hips, breasts and underarms, and weak muscles, according to the U.S. National Institutes of Health.

Internet trolls partly aided doctors in diagnosing Amy Schumer with Cushing syndrome, but patients can go years without a diagnosis. Schumer opened up about her February 2024 diagnosis on the “Call Her Daddy” podcast Wednesday, crediting online criticism about her swollen face – a telltale sign of the hormonal disorder.