Tamale is the capital city of the Northern Region of Ghana. It is Ghana's third largest city, with a population of 371,351 people. The city has be…Tamale is the capital city of the Northern Region of Ghana. It is Ghana's third largest city, with a population of 371,351 people. The city has been ranked as the fastest-growing city in West Africa. Tamale is located in the Kingdom of Dagbon, Ghana's oldest Kingdom. Major ethnic groups who resided in Tamale are Dagomba, Gonja, Mamprusi, Akan, and Dagaaba.