Cambridge is a city in Dorchester County, Maryland, United States. The population was 13,096 at the 2020 census. It is the county seat of Do…Cambridge is a city in Dorchester County, Maryland, United States. The population was 13,096 at the 2020 census. It is the county seat of Dorchester County and the county's largest municipality. Cambridge is the fourth most populous city in Maryland's Eastern Shore region, after Salisbury, Elkton and Easton.