The Replication Cycle of Varicella-Zoster Virus: Analysis of the ...
WEBFeb 4, 2009 · Although syncytium formation is a hallmark of VZV infection, infection of neighboring cells did not require cell-cell fusion; its occurrence from 9 h is likely to amplify VZV replication. Our results define the productive cycle of VZV infection in a single cell as occurring in 9 to 12 h.
VZV life cycle and replication. a | Model of the varicella zoster virus ...
WEBVaricella zoster virus (VZV) is a neurotropic alphaherpesvirus exclusively infecting humans, causing two distinct pathologies: varicella (chickenpox) upon primary infection and herpes...
Molecular mechanisms of varicella zoster virus pathogenesis
WEBa | Model of the varicella zoster virus (VZV) life cycle. VZV infects the human host when virus particles reach mucosal epithelial sites of entry. Local replication is followed by spread to tonsils and other regional lymphoid tissues, where VZV gains access to T cells.
The Biology of Varicella-Zoster Virus Replication in the Skin
WEBMay 6, 2022 · The replication of varicella-zoster virus (VZV) in skin is critical to its pathogenesis and spread. Primary infection causes chickenpox, which is characterised by centrally distributed skin blistering lesions that are rich in infectious virus.
Varicella zoster virus infection | Nature Reviews Disease Primers
WEBJul 2, 2015 · 394 Citations. 604 Altmetric. Metrics. Abstract. Infection with varicella zoster virus (VZV) causes varicella (chickenpox), which can be severe in immunocompromised individuals, infants and...
Molecular mechanisms of varicella zoster virus pathogenesis
WEBFeb 10, 2014 · a | Model of the varicella zoster virus (VZV) life cycle. VZV infects the human host when virus particles reach mucosal epithelial sites of entry.
The Biology of Varicella-Zoster Virus Replication in the Skin
WEBMay 6, 2022 · In this review, we outline the current knowledge on VZV interaction with host signalling pathways, the viral association with proteins associated with epidermal terminal differentiation, and how these interconnect with the VZV life cycle to facilitate viral replication and shedding.
Varicella-Zoster Virus Glycoproteins: Entry, Replication, and ...
WEBSep 9, 2016 · Varicella-zoster virus (VZV) is a pathogenic human alphaherpesvirus that causes varicella (chickenpox), a vesicular exanthem in children, and zoster (shingles), a severe exanthema that is typically restricted to a single dermatome in adults [1].
WEBlife cycle and new virus particles are produced. This damages the host cell, which, in skin cells, leads to the formation of blisters. Latent infection stops before new virus particles are produced
Varicella-Zoster Virus Infectious Cycle: ER Stress, Autophagic …
WEBDec 10, 2016 · Abstract. Varicella-zoster virus (VZV) induces abundant autophagy. Of the nine human herpesviruses, the VZV genome is the smallest (~124 kbp), lacking any known inhibitors of autophagy, such as the herpes simplex virus ICP34.5 neurovirulence gene.